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Another IMPETUX interview

IMPETUX interview at ESADECREAPOLIS webpage

 

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After participating in the IV edition of the EMPENTA program, organized by ACCIO and ESADECREAPOLIS, we were interviewed at ESADECREAPOLIS OPEN INNOVATION COMMUNITY.

You can read the complete interview in Spanish here.

 

 

A new interesting Optics Express article

Direct measurement of axial optical forces

Gregor Thalhammer, Lisa Obmascher, and Monika Ritsch-Marte

An Optics Express article talking about the direct measurement of optical forces based on recording the change of light momentum:  (the approach that overcomes many of the limitations of force measurements based on position measurements).


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IMPETUX has been at Trends in Optical  Micromanipulation III

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Arnau has given the talk:

Force measurements with optical tweezers inside living cells

And Ferran has been presenting the poster:

Implementation of Force Measurements based on the Detection of Light Momentum Changes in Optical Tweezers

In addition, many attendants have had the opportunity to see our demo and solve all their doubts about our method. Thank you very much to all of them for their interest!

IMPETUX will be at Trends in Optical Micromanipulation III

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Universitätszentrum Obergurgl

We are pleased to announce that we will be giving the following talk:

Force measurements with optical tweezers inside living cells

And presenting the following poster:

Implementation of Force Measurements based on the Detection of Light Momentum Changes in Optical Tweezers

We will be also  exhibiting a set up with a very interesting demo that will show the potentials of our technology!.

read more…

Arnau Farré has been awarded with the Justiniano Casas second prize for research in Optical Imaging

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Arnau Farré, co-founder of IMPETUX OPTICS, has been awarded with the Justiniano Casas second prize for research in Optical Imaging, 4th edition, for his thesis, entitled “Momentum measurements of single-beam traps and quantitative holographic experiments: two sides of the same coin”. The award ceremony was hold on the 29 of August in Santiago de Compostela during the meeting of the 23rd Congress of the International Commission for Optics (ICO).

Award Ceremony Press Note

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IMPETUX releases Deimus T-10i into the market!

The IMPETUX team is glad to announce the launch of the entry-level optical force measurement system: Deimus T-10i.

As a result of our continuous development activity we are proud to present our new T series system for Optical Tweezers

read more…

Events

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Key Bibliography

Here you will find useful material published related with our technology and products

Papers

Optical trapping has become an optimal choice for biological research at the microscale due to its noninvasiveperformance and accessibility for quantitative studies, especially on the forces involved inbiological processes. However, reliable force measurements depend on the calibration of the opticaltraps, which is different for each experiment and hence requires high control of the local variables,especially of the trapped object geometry. Many biological samples have an elongated, rod-likeshape, such as chromosomes, intracellular organelles (e.g., peroxisomes), membrane tubules, certainmicroalgae, and a wide variety of bacteria and parasites. This type of samples often requires severaloptical traps to stabilize and orient them in the correct spatial direction, making it more difficult todetermine the total force applied. Here, we manipulate glass microcylinders with holographic opticaltweezers and show the accurate measurement of drag forces by calibration-free direct detection ofbeam momentum.

Measuring forces inside living cells is still a challenge due the characteristics of the trapped organelles (non-spherical, unknown size and index of refraction) and the cell cytoplasm surrounding them heterogeneous and dynamic, non-purely viscous). Here, we show how two very recent methods overcome these limitations: on the one hand, forces can be measured in such environment by the direct detection of changes in the light momentum; on the other hand, an active-passive calibration technique provides both the stiffness of the optical trap as well as the local viscoelastic properties of the cell cytoplasm.

  • Martín-Badosa, F. Català, J. Mas, M. Montes-Usategui, A. Farré, F. Marsà. “Force measurement in the manipulation of complex samples with holographic optical tweezers” 15th workshop on Information Optics (WIO), 2016.
  • Derek Craig, Alison McDonald, Michael Mazilu, Helen Rendall, Frank Gunn-Moore, and Kishan Dholakia. “ Enhanced Optical Manipulation of Cells Using Antireflection Coated Microparticles”.ACS Photonics, 2 (10), pp 1403–1409, (2015).

    In molecular studies, an optically trapped bead may be functionalized to attach to a specific molecule, whereas in cell studies, direct manipulation with the optical field is usually employed. Using this approach, several methods may be used to measure forces with an optical trap. However, each has its limitations and requires an accurate knowledge of the sample parameters.6,7 In particular, force measurements can be challenging when working with nonspherical particles or in environments with an inhomogeneous viscosity, such as inside the cell. Recent developments in the field are moving toward obtaining direct force measurements by detecting light momentum changes. For this approach, the calibration factor only comes from the detection instrumentation and negates the requirement to recalibrate for changes in experimental conditions”.

  • Xing Ma, Anita Jannasch, Urban-Raphael Albrecht, Kersten Hahn, Albert Miguel-López, Erik Schäffer, and Samuel Sánchez. “Enzyme-Powered Hollow Mesoporous Janus Nanomotors”. Nano Lett., 15 (10), pp 7043–7050, (2015).

    “Using optical tweezers, we directly measured a holding force of 64 ± 16 fN, which was necessary to counteract the effective self-propulsion force generated by a single nanomotor. The successful demonstration of biocompatible enzyme-powered active nanomotors using biologically benign fuels has a great potential for future biomedical applications.”

 In this work, the authors show the feasibility of combining optical tweezers (single-beam gradient traps) with the determination of forces using the measurement of the light momentum change.

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