Solid-state confocal microscopy for fast, deep live-cell imaging.
Optical tweezers for quantitative assays from single molecules to living organisms.
PhaseStreak brings a solid-state approach to line-scanning confocal microscopy, enabling fast, deep imaging with direct control over illumination and optical sectioning.
A flexible platform combining programmable optical trapping, direct force measurement and fluorescence imaging to study molecular interactions, cellular mechanics and complex soft matter.
Explore our expertise in live-cell imaging and quantitative optical trapping.
PhaseStreak combines fast optical sectioning, efficient illumination and deep-sample imaging to support demanding live-cell and 3D fluorescence workflows.
Rapidly acquire volumetric fluorescence datasets.
Maintain optical sectioning and background rejection across thick samples.
Optimize sectioning and signal collection while illuminating only the region of interest.
Sequential acquisition at 405, 473, 561 and 639 nm.
Use optical trapping to investigate molecular interactions, cellular mechanics, biomolecular condensates and the physical properties of complex soft matter.
Investigate force generation, viscoelasticity and mechanotransduction in cells, tissues and living organisms.
Quantify molecular interactions and the dynamics of individual biomolecules, molecular motors and cytoskeletal filaments.
Investigate the mechanics, viscoelasticity and fusion dynamics of biomolecular condensates formed through liquid-liquid phase separation.
Characterize colloidal interactions and the rheological properties of complex and active materials
Solid-state confocal imaging and calibration-free optical tweezers.
Engineered in Barcelona at the intersection of photonics, physics and biology.
Multiple samples, workflows and research questions. One instrument.
Work directly with our team as your experiments evolve.
Sept 2025
Our second instrument platform combines quantitative phase imaging with high-speed confocal fluorescence.
July 2025
Collaborators at Institut Curie publish new findings in Nature Cell Biology.
May 2025
Live demos and a first look at PhaseStreak Confocal. Book a meeting with our scientists.
Tell us about your research, samples or experimental requirements. Our team will help you explore the right optical trapping or confocal imaging solution.
Time dependence of trap position (top), force signal (middle) and Ca2+ fluorescence signal (bottom) recorded during a membrane tether pulling experiment. The force and Ca2+ ion channel activity signals exhibit negative correlation.
Force and displacement data for two beads stimulated at frequencies of 4 Hz and 0.25 Hz. The progressive reduction of the beads displacement is in concomitancy with an increase of the applied force and loading rate.
Schematic representation of the optical tweezers experiment. A fibronectin-coated bead is trapped, brought into contact with the cell membrane and stimulated with oscillations at different frequencies.
Time dependence of trap 1 and trap 2 position (top) and force (bottom) data along the different steps of the described dual tether pulling experiment.
Confocal video of the described dual tether pulling assay performed on a neuron axon. Courtesy of M. Krieg lab (ICFO).
Time dependence of trap position (top), force signal (middle) and Ca2+ fluorescence signal (bottom) recorded during a membrane tether pulling experiment. The force and Ca2+ ion channel activity signals exhibit negative correlation.
Confocal video showing a DVA neuron Ca2+ ion channel activity in a dynamic optical trapping assay. The pulling rate applied to the membrane tether is progressively increased. Scale bar = 5µm. Acquired at 10Hz.