optical tweezers for mechanobiology SENSOCELL

A novel optical tweezers concept for cell and tissue mechanobiology.

optical tweezers force measurements with SENSOCELL

A unique Force sensor technology:

 

  • No calibrations needed.
  • Measure forces inside living cells and tissues.
  • Simultaneous measurements on multiple traps.
  • Measure on non-spherical objects.
  • 3D Force measurements.
SENSOCELL optical manipulation module

Multiple optical traps generation module:

 

  • Up to 256 traps.
  • AOD beam steering technology.
  • 25 kHz trap steering frequency.
  • 5W, 1064 nm single-frequency laser.
  • Compatible with different microscopies (BF, epi-FL, DIC, TIRF, Confocal…).
SENSOCELL LightAce software

Automated routines for cell mechanobiology:

 

  • “Click and Drag” trapping mode.
  • Active & passive micro-rheology.
  • Tether pulling routines.
  • Custom trap oscillations & trajectories.
  • Force clamp mode.
  • Trap stiffness & position calibration.
  • Create your own routines using LightAce SDK!

IMPETUX – Optical Tweezers for Mechanobiology


Impetux is a worldwide key manufacturer and supplier of turnkey optical tweezers systems designed for mechanobiology studies in living cells and 3D tissues. Based on our distinctive and worldwide patented technology, SENSOCELL™ allows manipulating and deforming cells as whole or even endogenous structures such as the cell membrane, the cell nucleus, vesicles and other organelles while tracking the in vivo biological forces involved, even inside living tissues. Discover the insights of the rich world of cell mechanobiology in studies like cell micro-rheology, nucleus mechanotransduction, cell membrane mechanics, molecular motor activity and cell-cell interactions. SENSOCELL™  enables outstanding and unprecedented optical trapping experiences to explore new ways to boost your research.

Optical tweezers platform – SENSOCELL™


optical tweezers for mechanobiology SENSOCELL
  • Generate up to 256 optical traps thanks to its AOD beam steering technology enabling extensive manipulating control over them.
  • Get direct force measurements inside cells and tissues. No previous calibrations are needed: just trap & measure!
  • Track simultaneous force measurements over multiple independent traps.
  • Measure forces applied either over trapped exogenous spherical particles or directly over whole cells or endogenous trappable cellular structures such as lipid vesicles, membranes or nuclei.
  • A wide variety of imaging techniques compatibility (BF, epi-FL, DIC, TIRF, Confocal…).
  • Use our predefined & customizable routines for cell mechanobiology: force clamp, active & passive micro-rheology, cell stretching, tether pulling…
  • …or create your own routines using our simple LightAce Software Development Kit!
  • Includes an ultra-stable single-frequency laser source (5W, 1064 nm) for the best performance in frequency-dependent studies.

SENSOCELL product page LightAce software Force sensor technology Optical manipulation technology

Applications for Cell & Tissue Mechanobiology


optical tweezers application for cell mechanobiology: membrane tension and tether pulling
Tether Pulling

Study cell membrane mechanics in cells and explants performing tether pulling experiments. Use our customizable routines or create your own tether pulling routines.

optical tweezers application for cell mechanobiology: immune cell-cell interactions.
Immune Cells Interactions

Manipulate whole cells to engage cell-cell interactions and measure their binding forces while having absolute control on cells orientation and contact time. Use functionalized beads and/or substrates to measure in vitro receptor-ligand binding forces.

optical tweezers application for cell mechanobiology: micro-rheology
Active Micro-Rheology

Perform active & passive micro-rheology experiments in viscoelastic media like cell’s cytoplasm, hydrogels or biofilms.

optical tweezers application for cell mechanobiology: whole cell and nucleus shape deformation and stretching
Cell & Nucleus Deformation

Study cell membrane and cell nucleus mechanotransduction pathways by stretching the cell as a whole or manipulating the cell nucleus.

optical tweezers application for cell mechanobiology: membrane mechanoreceptors. Cell-ECM interactions
Cell-ECM Interactions

Study the dynamics and forces of transmembrane mechanoreceptors in cell-ECM interactions at the single-molecule level.

optical tweezers application for cell mechanobiology: motor proteins activity
In Vivo Motor Proteins Activity

​Study the activity and kinetics of motor proteins in vitro and in vivo. Measure stall forces of protein motors and observe tug-of-war and cooperating phenomena.

Are you thinking in a different application? Contact us and we will be happy to discuss it!

Would you like a DEMO?

We will be pleased to prepare an in situ or a remote demo for you.

 Sure! 

Download SENSOCELL™ optical tweezers brochure

 

Contact us:

impetux@impetux.com

(+34) 93 185 69 38

Visit us:

Mallorca 93 | 08029 Barcelona

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