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News

Collaborations to carry out cutting edge research

Impetux collaborates with several Mechanobiology Research projects. Nucleux is one of them.

With an interdisciplinary vision: physics, biology, mathematics and medicine, the project aims to understand the basic mechanisms behind the complexity of the cell nucleus, and our Sensocell system will be key in this challenge.

With 6 research groups participating, after a first year of the project, this great team have already results and first publications!. Find out more about them at:  https://www.nucleux.es/resultados/

Congratulations!

 

H2020 Funding

We are pleased to announce that we have been awarded with the European Comission funding (SME phase 1 instrument), to explore and validate a revolutionary application of our patented technology for force measurement in tissues and living cells. The innovation that represents this new application, will have a high impact on biomedical research and will boost the company growth.

IMPETUX WITH BIOMEDICAL RESEARCH

Impetux is collaborating in the Innovation in the HealthCare sector with photonic technologies Program designed by SECPHO (Southern European Cluster in Photonics & Optics) and ITEMAS ( Medical Technology Innovation Platform)

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Events

WEBINAR OCTOBER 22, 2020

Introducing SENSOCELL: Optical Tweezers for Mechanobiology

DATE: October 22, 2020
Time: 19h CET (Paris, GMT+2)

Optical tweezers for mechanobiology SENSOCELL

SENSOCELL is an optical tweezers system, designed for mechanobiology studies in living cells and 3D tissues. It allows manipulating and deforming cells as whole or even endogenous structures such as the cell membrane, the cell nucleus, vesicles and other organelles while tracking the in vivo biological forces involved thanks to its unique direct force sensor technology.

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Cell Physics 2019

From the 9th to the 11th of October we will have the pleasure to be at Cell Physics 2019 at the Saarland University in Saarbrücken, Germany. A conference organized by the Collaborative Research Center SFB 1027 “Physical modeling of non-equilibrium processes in biological systems”.

There, we will be delighted to share with you all the news related with our systems, the solutions and the amazing new opportunities they offer related with Cell mechanics, mechanobiology, cell adhesion, cell membrane and oncoimmunology. Do not lose the opportunity to visit us!.

More information about the conference here.

Scientific Publications

Here you will find useful material published related with our technology and products.

 

Papers:

 

For additional information, have a look at:

In this study, the authors used a customized optical trapping system from IMPETUX to characterize cell membrane elasticity as a new potential biomarker for leukemia cells, comparing measurements for cells treated with anti-cancer drugs and untreated cells.

 

Optical trapping has become an optimal choice for biological research at the microscale due to its noninvasiveperformance and accessibility for quantitative studies, especially on the forces involved inbiological processes. However, reliable force measurements depend on the calibration of the opticaltraps, which is different for each experiment and hence requires high control of the local variables,especially of the trapped object geometry. Many biological samples have an elongated, rod-likeshape, such as chromosomes, intracellular organelles (e.g., peroxisomes), membrane tubules, certainmicroalgae, and a wide variety of bacteria and parasites. This type of samples often requires severaloptical traps to stabilize and orient them in the correct spatial direction, making it more difficult todetermine the total force applied. Here, we manipulate glass microcylinders with holographic opticaltweezers and show the accurate measurement of drag forces by calibration-free direct detection ofbeam momentum.

Measuring forces inside living cells is still a challenge due the characteristics of the trapped organelles (non-spherical, unknown size and index of refraction) and the cell cytoplasm surrounding them heterogeneous and dynamic, non-purely viscous). Here, we show how two very recent methods overcome these limitations: on the one hand, forces can be measured in such environment by the direct detection of changes in the light momentum; on the other hand, an active-passive calibration technique provides both the stiffness of the optical trap as well as the local viscoelastic properties of the cell cytoplasm.

  • Martín-Badosa, F. Català, J. Mas, M. Montes-Usategui, A. Farré, F. Marsà. “Force measurement in the manipulation of complex samples with holographic optical tweezers” 15th workshop on Information Optics (WIO), 2016.
  • Derek Craig, Alison McDonald, Michael Mazilu, Helen Rendall, Frank Gunn-Moore, and Kishan Dholakia. “ Enhanced Optical Manipulation of Cells Using Antireflection Coated Microparticles”.ACS Photonics, 2 (10), pp 1403–1409, (2015).

    In molecular studies, an optically trapped bead may be functionalized to attach to a specific molecule, whereas in cell studies, direct manipulation with the optical field is usually employed. Using this approach, several methods may be used to measure forces with an optical trap. However, each has its limitations and requires an accurate knowledge of the sample parameters.6,7 In particular, force measurements can be challenging when working with nonspherical particles or in environments with an inhomogeneous viscosity, such as inside the cell. Recent developments in the field are moving toward obtaining direct force measurements by detecting light momentum changes. For this approach, the calibration factor only comes from the detection instrumentation and negates the requirement to recalibrate for changes in experimental conditions”.

  • Xing Ma, Anita Jannasch, Urban-Raphael Albrecht, Kersten Hahn, Albert Miguel-López, Erik Schäffer, and Samuel Sánchez. “Enzyme-Powered Hollow Mesoporous Janus Nanomotors”. Nano Lett., 15 (10), pp 7043–7050, (2015).

    “Using optical tweezers, we directly measured a holding force of 64 ± 16 fN, which was necessary to counteract the effective self-propulsion force generated by a single nanomotor. The successful demonstration of biocompatible enzyme-powered active nanomotors using biologically benign fuels has a great potential for future biomedical applications.”

 In this work, the authors show the feasibility of combining optical tweezers (single-beam gradient traps) with the determination of forces using the measurement of the light momentum change.

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