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SENSOCELL used to demonstrate the mechanism tissues use to regulate their sensitivity to mechanical signals

SENSOCELL used to demonstrate the mechanism tissues use to regulate their sensitivity to mechanical signals

A new publication recently released shows how our OT platform SENSOCELL is used to demonstrate the mechanism tissues use to regulate their sensitivity to mechanical signals.
The labs of Pere Roca-Cusachs and Xavier Trepat (IBEC) use SENSOCELL to perform active microrheology experiments and investigate how laminin-integrin links influence mechanotransduction in mammary epithelial cells.

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Soft condensed matter, nonlinear rheology and SENSOCELL

Soft condensed matter, nonlinear rheology and SENSOCELL

Delighted to share a new publication recently released that shows another interesting application of SENSOCELL.
In this work, Dr Ahmed et al. analyze the dynamics of a passive colloidal probe immersed in an active bath using Optical tweezers in combination with our force spectroscopy technology .
If you are interested in soft condensed matter and nonlinear rheology do not miss it ! .

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Mechanical cues trigger neuronal activity and ion channel receptors

Mechanical cues trigger neuronal activity and ion channel receptors

Finally! The latest paper from the Neurophotonics & Mechanical Systems Biology group at ICFO has been published in SCIENCE ADVANCES. In this work entitled “An asymmetric mechanical code ciphers curvature-dependent proprioceptor activity”, the mechanical activation of neuronal activity in C. elegans is studied by means of genome editing, modelling and direct force spectroscopy integrated in SENSOCELL optical tweezers.

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New protocol for the study of subcellular mechanics in confinement

New protocol for the study of subcellular mechanics in confinement

In this work the authors describe in detail a protocol using SENSOCELL optical tweezers to interrogate the mechanical properties of the cell nucleus inside living cells and that can be extended to the study of other subcellular compartments and organelles. As a representative result, the authors used DNA-Hoechst staining to measure the nucleus deformation upon indentation performed by forces of the order of several hundreds of pN.

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