Measuring the forces applied to the nucleus with SENSOCELL:
Researchers from Insitut de Ciències Fotòniques (ICFO) , Centre for Genomic Regulation (CRG), Universitat Pompeu Fabra (UPF) and University of Applied Science Upper Austria have recently published an amazing Science article in where they show that the nucleus, the biggest organelle in the cell, translates cell shape changes into a deformation signal regulating cell behavior.
In this study, our optical tweezers system SENSOCELL has been used to precisely measure the forces applied to the nucleus, determine its deformation and obtain its mechanical properties.
“Our work represents a paradigm shift where the nucleus itself is not simply a static-container of genetic material but rather a dynamic sensor that cells can use to make sense of the environment around them,” says Valeria Venturini the first author of the publication. “The intensity of nuclear stretching predicted the intensity of the response, shedding new light on this ‘fight or flight’ reflex at the single cell level.Understanding this ability to sense deformation, measure it and react accordingly may have important implications in understanding processes like cancer growth and homeostasis.”
You can review all the results here -> Science Publication .
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Congratulations to the authors !