We will be at Nanoengineering for Mechanobiology N4M 2022 edition
If you are a researcher in Mechanobiology or an enthusiast of Engineering and Cell Biology, you cannot miss the conference Nanoengineering for Mechanobiology N4M 2022 edition organized by Massimo Vassalli (Glasgow University) and that will take place in the beautiful town of Camogli (Italy).
IMPETUX will participate at the conference: AQV DAYS 2022 : QUANTITATIVE APPROACHES TO LIVING SYSTEMS organized by the Institute Jacques Monod (France). The conference is open to all members of the AQV network as well as to all researchers tackling biological questions with methods coming from physics, chemistry, engineering or other sciences.
📅DATE: 19 to 21 January 2022 (CEST)
Stay tuned for future news about our participation in this conference !
If you are attending the event, join us at our exhibitor showcase talk:
SENSOCELL: A multiple optical trapping platform combining direct force spectroscopy & fluorescence imaging
📅DATE: Thursday 22th July at 1:00 PM (Singapore time)
We will show the advantages of our patented direct force spectroscopy technology and explain how we overcome the classical limitations of optical tweezers turning them into a high-level tool for mechanobiology.
You can head over to the event website to check out the complete program here.
This EMBO Workshop will explore the intersection between polarity, cytoskeleton and cellular membrane networks in the context of polarized cells and tissues. It will bring together researchers from around the globe and across career stages to identify and highlight new principles of cellular organization and how these concepts impact our understanding of the role of polarity and membrane dynamics in human development and disease.
We will be participating with a talk and a Q&A session to show how our patented cutting-edge technology can be a fundamental tool to reveal new understanding in this amazing field.
The talk will be 🎥 pre-recorded and made available to registered participants.
📅May 17, at 15:30 h. CET we will be on a live discussion session to answer all your questions.
A great opportunity to meet comfortably for discussion and feedback!
You can head over to the event website to check out the program and register here.
Arnau Farré, our CTO , will be giving an interesting scientific talk:
📅DATE: May 6, 2021 | 17:25h CET | ONLINE
If you are interested in new cutting edge mechanobiology technology can’t miss it. Join us online for the exciting talk:
Cell nucleus indentation, micro-rheology, tether pulling & other cell mechanobiology applications of the SENSOCELL optical tweezers platform.
Optical tweezers (OT) were first applied to biology research questions in the early 90s, and since then they have been primarily used for molecular biology applications. Conversely, their use on cell biology research has been greatly limited to trapping experiments intended for moving or manipulating living cells. The sparsity of quantitative experiments using OT in living cells is mainly due to the difficulties in measuring readily and accurately the forces applied by OT onto the probed samples. Here we present our distinctive patented technology (SENSOCELL) for mechanobiology research, which allows users to carry out direct force measurements in vitro, in vivo or in situ. Forces are applied either via exogenous spherical particles or directly to endogenous trappable cellular structures such as lipid vesicles, membranes, nuclei or whole cells. Forces are measured based on the ‘light momentum method’ and via our unique technology which allows the detection in our sensor of all light scattered off the trap. Using this approach, the readout from our light sensor yields directly the force applied by the OT via a constant that is unique, permanent and calibrated at factory. Measurement protocols are thus unhindered by recurrent trap stiffness calibrations, allowing measurements to be carried out in an easy and speedy manner by non-expert users. Furthermore, the flexibility offered by individual force measurements of simultaneous multiple traps (up to 256) increases throughput and allows advanced protocols such as trapping of large objects, cell stretching or the measurement of cell-cell interaction forces. SENSOCELL is also capable of performing active micro-rheology experiments in biological samples and scaffolds, such as soft hydrogels, up to the kPa range in stiffness and kHz range in probing frequency. Additional applications include cell nucleus indentation, measurement of membrane tension, membrane tether pulling or cell-cell interactions. Importantly, all applications can be combined with simultaneous fluorescence imaging. In our presentation, we will shortly introduce the key distinctive features of our technology and show examples and results obtained by our customers and scientific collaborators for the aforementioned applications in living cells.
Looking forward meeting you there!
If you haven’t done it yet, you can register here.
If you are interested in new cutting edge mechanobiology technology can’t miss the webinar series organized by Massimo Vassalli from the Cellular Mechanobiology Lab at the University of Glasgow and N4M:Nanoengineering for Mechanobiology.
Join us online for the exciting talk:
Light as a tool for mechanobiology : Introducing SENSOCELL optical tweezers
During my talk, I will highlight recent progress to understand the interplay between cellular and molecular nanomechanics and their role in regulating cellular physiology. I focus on work on the nervous system of the roundworm Caenorhabditis elegans, which is a popular experimental system to combine engineering, biophysics and cell biology, due to its stereotyped body plan, known structural connectome and amenable genetics. C elegans uses a set of different sensory neurons to navigate its habitat which endow the animals to process chemical and mechanical stimuli in a changing environment. Some of these neurons respond to minute mechanical forces delivered to the skin of the animal, while others respond to stresses generated within the animals that originate from muscle contraction during locomotion. How these stresses are borne by molecular mechanics, transmitted within biological tissues and activate biochemical pathways is one of the last challenges in mechanosensory biology. This lack of understanding is largely due in part to the absence of appropriate techniques to investigate the effect of mechanical properties of cells and neurons within living organisms at the level of a single molecule. In this webinar, I will highlight some recent efforts from our lab to further our understanding of how mechanical stresses distribute within cells and enable mechanosensory behavior such as touch and proprioception.
Looking forward meeting you there! You only need to register here.
📅DATE: March 12, 2021 | 10 AM PST / 1 PM EST | 7 PM CET
SENSOCELL is an optical tweezers system with multiple trap generation capability including a force measurement module, and is designed for mechanobiology studies in living cells and 3D tissues.
During this webinar we will introduce the technology of optical tweezers, present the SENSOCELL platform and show some application examples including the latest data acquired with SENSOCELL.
We will conclude with an open Q&A session.
The webinar will last 45 minutes.
Who Should Attend this Webinar?
Scientists and researchers interested in mechanobiology studies, pattern morphing applications including organic or non-organic particles and liquid crystals, or just curious scientists interested in optical tweezing and manipulation of really tiny things.
A great opportunity to meet comfortably from wherever you want!